Targeting MRS-Defined Dominant Intraprostatic Lesions with Inverse-Planned High Dose Rate Brachytherapy

Abstract

During these three years we have obtained CHR approval (December 2004)from the three step process (G.U. P.R.C. and C.H.R.) committees at UCSF. D.O.D. CHR approval was finally obtained in December 2006. Patient enrollment will begin immediately after receiving UCSF-CHR re-confirmation. We have developed a deformable image registration method to improve the quality of registration of (probe-in) MRSI data for (probe-out) radiation treatment planning. A similarity index (SI) of 98.1 % was obtained for rigid probe patient data. We have also obtained a class solution for the boost of DIL defined by MRI/MRSI as well as for the sparing of organs at risk including bladder rectum urethra and penile bulb. Patients enrollment will be initiated shortly.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2007
Accession Number
ADA470893

Entities

People

  • I-chow Hsu
  • Jean Pouliot
  • John Kurhanewicz
  • Sue Noworelski

Organizations

  • University of California, San Francisco

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Anatomy
  • Biomedical Research
  • Demographic Cohorts
  • Department Of Defense
  • Dose Rate
  • Image Registration
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Prostate Cancer
  • Radiation
  • Radiation Oncology
  • Radiotherapy
  • X-Ray Computed Tomography

Fields of Study

  • Medicine
  • Physics

Readers

  • Medical Imaging.
  • Oncology and Biomarker-Based Cancer Detection.