Contribution of AMACR and Phytanic Acid to Prostate Cancer Risk Among African Americans in North Carolina
Abstract
Several lines of evidence have suggested genetic and dietary differences may be important in PCa, particularly among AA (African American) men. In this study, we aim to test the hypothesis that mutations/sequence variants in the AMACR gene, and dietary intake of foods rich in phytanic acid, increase the risk to PCa among AA men. We will conduct a population based study by ascertaining 250 AA men who have PCa and 250 race, age, and county-matched controls from eight counties of North Carolina. We are in the process of carrying out the 1st task, study subject recruitment, until year 2008. In the past funding year, we have obtained IRB approval and started subject recruitment. We have also contacted other investigators to explore the possibility of expanding our study area. Additionally, we have also submitted two additional grant applications to investigate genetic and environmental risk factors based on this study population. The results from this study, as well as other future studies based on this study population, will greatly increase our knowledge for potential risk factors and suggest potential preventive strategies for prostate cancer in AA men.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2007
- Accession Number
- ADA471007
Entities
People
- Bao-li Chang
Organizations
- Wake Forest University