The Impact of the 6:3 Polyunsaturated Fatty Acid Ratio on Intermediate Markers of Breast Cancer

Abstract

Extensive experimental evidence has shown the intake of omega-6 polyunsaturated fatty acids (PUFAs) promotes breast cancer (1), while consumption of omega-3 PUFAs inhibits this disease. (2) Furthermore, it appears that the cancer promoting activity of the omega-6 fatty acids is abrogated by the competitive inhibition of omega-3 fatty acids (3,4). Although the mechanism by which the 6:3 PUFA ratio may promote breast cancer is unknown, it is suggested that a high 6:3 PUFA ratio may influence breast cancer is unknown, it is suggested that a high 6:3 PUFA ratio may influence breast cancer risk by increasing prostaglandin E2 (PGE2) synthesis thereby inducing estrogen production, via upregulation of aromatase.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2007
Accession Number
ADA471158

Entities

People

  • Alana Hudson

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Anti-Inflammatory Agents
  • Biomedical Research
  • Blood
  • Blood Cells
  • Body Weight
  • Breast Cancer
  • Cancer
  • Fatty Acids
  • Health
  • Health Services
  • Hormones
  • Pennsylvania
  • Production
  • Public Health
  • Schools
  • Statistical Analysis

Readers

  • Breast cancer cell signaling and growth regulation.
  • Prostate Cancer Biology.