Optimization of Broad-Spectrum Antimicrobial Activity for Novel Compound Classes

Abstract

This final report summarized the results obtained from the preparation, evaluation, and extensive SAR analysis of hundreds of compounds with an emphasis on improving the antimicrobial activity of three compound classes outlined in our original proposal. the first class include the substituted pyranosyl cytosines, the second class of compounds are the heterobiaryl guanidines, ant the third are bis-heteroarylamidrazones

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2005
Accession Number
ADA471417

Entities

People

  • Richard H. Griffey

Tags

DTIC Thesaurus Topics

  • Anti-Infective Agents
  • Chemical Compounds
  • Cytosine
  • Guanidines
  • Optimization
  • Organic Compounds
  • Spectra
  • Test And Evaluation

Readers

  • Military/Explosive Ordnance Disposal (EOD) Technology
  • Operations Research
  • Parasitology and Pharmacology of Malaria.