The Role of Telomeric Repeat Binding Factor 1 (TRF1) in Telomere Maintenance and as a Potential Prognostic Indicator in Human Breast Cancer
Abstract
The aims of this study are to (i) determine the relationships between the telomere binding protein Telomere Repeat Binding Factor I (TRFI) and other telomere binding prnteins (ii) establish the potential of TRFI as a surrogate marker for telomere content (TC) and as a potential clinical marker and (iii) characterize the relationship between of the telomere binding protein TRFI and TC. Through examining the role of TRFI in telomere length control and in breast cancer prngrnssion this project also fosters the education of the candidate through the interaction with several experts in breast cancer pathology biostatistics and clinical and basic research. The experiments involved require the interaction with professionals from several different fields of the biomedical sciences and the mastery of several challenging laboratory techniques. To date all specific aims; as outlined in the Statement of Work are expected to be completed on schedule. The research is in progress.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2007
- Accession Number
- ADA471441
Entities
People
- Jeffrey K. Griffith
- Kimberly S. Bulter