A Genetic Approach to Define the Importance of Rheb in Tuberous Sclerosis

Abstract

We have made progress in characterizing Rheb2, examining effects of the TSC/Rheb/mTOR signaling on cell cycle progression, investigating mechanism of activation of mTOR and examining consequences of the activation of the TSC/Rheb/mTOR signaling pathway. We have shown that the TSC/Rheb/mTOR signaling pathway affects nuclear translocation of a Cdk2 inhibitor, p27. Novel activating mutations of mTOR were identified. Consequences of the activation of the TSC/Rheb/mTOR signaling pathway on cell physiology are being investigated. Our study makes significant contribution to understand how the TSC/Rheb/mTOR signaling pathway is regulated. Our investigation into cellular consequences of the activation of this pathway is important in understanding tuberous sclerosis.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2007
Accession Number
ADA471491

Entities

People

  • Fuyuhiko Tamanoi

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Antibodies
  • Biomedical Research
  • California
  • Cell Cycle Proteins
  • Cell Line
  • Cell Physiological Processes
  • Cell Physiology
  • Cell Size
  • Cells
  • High Density
  • Inhibitors
  • Kinases
  • Mutations
  • Nutrition Disorders
  • Proteins
  • Sclerosis

Fields of Study

  • Biology

Readers

  • Aquatic Ecology
  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology