Radiation Sensitization in Breast Cancer via Targeting Survivin Expression

Abstract

We proposed to determine whether overexpression of survivin results in radioresistance and the possible mechanisms; whether regulators of survivin serve as targets for radiosensitization. We also found that deregulation of survivin in breast cancer is mediated by Stat3 (Signal transducer and activator of transcription). Co-inhibition of survivin and Stat3 results in significantly increased sensitization of breast cancer. In addition we found that inhibition of apoptosis induces autophagy in cell culture model of breast cancer. Z-VAD a pan-caspase inhibitor resulted in further tumor growth delay in a xenograft model of breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2007
Accession Number
ADA471507

Entities

People

  • Bo Lu

Organizations

  • Vanderbilt University

Tags

DTIC Thesaurus Topics

  • Angiogenesis
  • Apoptosis
  • Autophagy
  • Biomedical Research
  • Body Weight
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Combination Therapy
  • Culture Techniques
  • Endothelial Cells
  • Histological Techniques
  • Inhibition
  • Inhibitors
  • Lung Cancer
  • Neoplasms
  • Therapy

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Oncology (Cancer Research).