Regulated GDNF Delivery in Vivo Using Neural Stem Cells

Abstract

This year we have confirmed that hNPC delivering GDNF can protect dopamine neurons in a rat model of Parkinson's disease and have now shown an improvement in behavioral asymmetry induced by the lesion. We have completed a large monkey study using GDNF-hNPC and are in the process of analyzing those data. We have published regulated vector data described last year and have two other papers under review for publication. We were awarded a one year no cost extension with (new aims and goals) to this grant which is currently underway.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2007
Accession Number
ADA471929

Entities

People

  • Clive Svendsen

Organizations

  • University of Wisconsin–Madison

Tags

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Asymmetry
  • Brain
  • Cell Physiological Processes
  • Cells
  • Department Of Defense
  • Diseases And Disorders
  • Dopamine
  • Gene Therapy
  • Growth Factors
  • Neurodegeneration
  • Neurons
  • Parkinson'S Disease
  • Stem Cells
  • Surgery
  • Therapy

Readers

  • Clinical Trial Research.
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.
  • Systems Analysis and Design

Technology Areas

  • Biotechnology