Influences of Nutrition and Physical Forces on Bone Structure/Function Properties

Abstract

The specific goals of this research program were to contribute to two major objectives in support of reducing the incidence of fracture: 1. The development and application of micro-imaging and testing techniques in animal models to study bone structure function properties. 2. Exploring the influence of calcium and vitamin D metabolism and physical forces on bone integrity. Using mouse models, this study demonstrated that the use of micro-imaging techniques (Micro CT, Raman Spectroscopy) and micro-mechanical testing methods (femora; 4 pt. bending , vertebral compression, tibial torsion) can effectively characterize the morphologic and mechanical properties of bone and how they may be altered by nutrition, exercise and gender. While the results illustrated little or no effect of exercise, the properties of the bone are significantly influenced by mouse strain, gender, and calcium intake.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2005
Accession Number
ADA471937

Entities

People

  • Barbara Mccreadie
  • Michael J. Morris
  • Steven A. Goldstein

Organizations

  • University of Michigan

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Bone And Bones
  • Bone Diseases
  • Bone Fractures
  • Chemical Synthesis
  • Chemistry
  • Computational Science
  • Crystal Lattices
  • Crystal Structure
  • Factor Analysis
  • Genetics
  • Mechanical Properties
  • Mechanics
  • Medical Personnel
  • Raman Spectroscopy
  • Scattering
  • Spectroscopy
  • Test Methods

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