The Nuclear Death Domain Protein p84N5; A Candidate Breast Cancer Susceptibility Gene

Abstract

Efforts to identify genes that contribute to breast cancer lead to the discovery of the human TREX complex, a group of proteins that work together to accurately process and transport messenger RNAs from the nucleus to the cytoplasm in a cell. A member of this complex, referred to as p84N5 (more recently named hTREX84) was found to be a culprit of aggressive human breast cancers. hTREX84 is expressed at very low levels in normal breast epithelial cells, but is highly expressed in breast tumors. hTREX84 expression correlates with tumor size and the metastatic state of the tumor progression. Inhibition of hTREX84 levels via RNAi approaches blocks breast tumor cell growth and causes the cells to die. Thus, hTREX84 appears to be a prognostic marker for determining the aggressiveness of breast cancer and may also be an ideal target for therapeutic drugs against breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2007
Accession Number
ADA472021

Entities

People

  • Andrew Godwin

Organizations

  • Fox Chase Cancer Center

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Carcinoma
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Dna Sequence Analysis
  • Epithelial Cells
  • Genetics
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Proteins
  • Spreadsheet Software

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and genetic basis of cancer.
  • Oncology