Targeting siRNA Missiles to HER2+ Breast Cancer
Abstract
The most significant finding of the research period reported here is that delivery conjugates can be assembled that can direct siRNA molecules to target cells, including HER2+ human breast cancer cells, in culture in the presence of serum, while non-target cells are avoided. The successful siRNA delivery in serum resulted in substantial reduction of target gene expression in the specific cells being aimed at by these missile-like molecules. These findings suggest that the approach of using our lab s novel targeting and cell penetration proteins may be effective at targeting specific tumor cells in vivo, which will be tested in our upcoming funding periods.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2007
- Accession Number
- ADA472023
Entities
People
- Lali K Medina-Kauwe
Organizations
- Cedars-Sinai Medical Center