Effects of Hematopoietic Lineage and Precursor Age on CML Disease Progression
Abstract
Declines in lymphopoiesis during aging diminish the immune response, but little consideration has been given to its effect on the development of hematological disease. This report demonstrates that age-related defects in lymphopoiesis contribute to the myeloid dominance of adult leukemia. Using a murine model of chronic myeloid leukemia (CML), an adult-onset malignancy arising from transformation of hematopoietic stem cells (HSC) by the BCR-ABLP210 oncogene, our studies have demonstrated that young bone marrow (BM) cells transformed with BCR-ABLP210 initiated both a myeloproliferative disorder (MPD) and B lymphoid leukemia while BCR-ABLP210 transformed old BM cells recapitulated the human disease by inducing a MPD with rare lymphoid involvement. Further, the lesser severity of MPDs initiated from old BCR-ABLP210 transduced BM cells revealed unappreciated defects in aged
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2007
- Accession Number
- ADA472050
Entities
People
- Kenneth Dorshkind
Organizations
- University of California, Los Angeles