The Role of Vitamin D Stimulation of Mullerian Inhibiting Substance (MIS) in Prostate Cancer Therapy

Abstract

We propose that MIS regulation may be an important element contributing to the ability of 1,25- dihydroxyvitamin D3 (calcitriol) to inhibit the growth and progression of prostate cancer cells. We have shown that calcitriol acts by several pathways to inhibit the growth of prostate cancer cells [1-5]. In the current studies we show that calcitriol also stimulates the expression of MIS in a standard human prostate cancer cell line, LNCaP. We further show that the up-regulation of MIS expression is mediated directly by calcitriol binding to the vitamin d receptor (VDR) and the complex subsequently interacting with a vitamin D regulatory element (VDRE) in the MIS gene promoter.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2006
Accession Number
ADA472122

Entities

People

  • David Feldman

Organizations

  • Stanford University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Cell Line
  • Cells
  • Department Of Defense
  • Electronic Mail
  • Gene Expression
  • Information Operations
  • Mutations
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Regulations
  • Transcription Factors
  • Transfection
  • Vitamin D

Fields of Study

  • Biology
  • Medicine

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Game Theory.
  • Prostate Cancer Biology.