High Resolution X-Ray Phase Contrast Imaging with Acoustic Tissue-Selective Contrast Enhancement

Abstract

We show that laser-driven thermal modification can be used to selectively enhance regions of a flowing carbon suspension. The preliminary proof-of-principle experiments illustrate the ability to measure thermal modifications in a time-resolved manner utilizing x-ray phase-contrast imaging paving the way for implementation in a biological model. Additional results of biological tissue sample measurements are presented. X-ray phase-contrast images of murine hepatic and pulmonary samples reveal fine structure usually visible only by utilizing histological or microscopy techniques. The method holds promise for future applications to study murine models of pulmonary and hepatic disease.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2007
Accession Number
ADA472126

Entities

People

  • Gerald J. Diebold

Organizations

  • Brown University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cartesian Coordinates
  • Computers
  • Contrast
  • Electromagnetic Radiation
  • High Resolution
  • Imaging Techniques
  • Laser Beams
  • Lasers
  • Liquid Jets
  • Physical Properties
  • Radiation
  • Refractive Index
  • Soft Tissues
  • Tissues
  • X Rays
  • X-Ray Computed Tomography

Fields of Study

  • Physics

Readers

  • Medical Imaging.
  • Pulsed Power and Plasma Physics.
  • Systems Analysis and Design

Technology Areas

  • Directed Energy