Time-Resolved and Spectroscopic Three-Dimensional Optical Breast Tomography
Abstract
The research carried out during the current reporting period included: (a) Use of optical tomographic imaging using independent component analysis (OPTICA) developed during the first reporting period to image targets in ex vivo breast tissue specimens, (b) Extension of OPTICA for obtaining cross sectional image of targets in turbid media, (c) (d) Development of a forward model for scattered light intensity distribution in the backscattering geometry; and (e) Development of an approach for determination of light absorption, scattering characteristics and anisotropy factor of a highly scattering medium using backscattered circular polarized light. The OPTICA approach was able to detect and provide the location of a tumor in a model breast composed of ex vivo breast tissues, and of a fluorescent target inside another model breast with millimeter accuracy. The forward model is suitable for describing polarized light propagation and imaging in backscattering geometry. Oblique incidence backscattering method for determination of optical properties has potential application in identifying breast tissue specimen as normal or cancerous. These developments prepare us for undertaking in vivo measurements. The graduate student supported by the project defended his Ph. D. thesis, adding another scientist to the ongoing fight against breast
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2007
- Accession Number
- ADA472335
Entities
People
- Robert Alfano
Organizations
- State University of New York