Combined MR and Optical Imaging System for Noninvasive Tumor Characterization and Quantification of Oxygenation Gain Factor in a Breast Cancer Animal Model
Abstract
This study proposes to modify and improve an existing MR-compatible optical tomography system that is used for non-invasive tumor characterization and provides higher sensitivity and specificity for cancer imaging. The proposed research will conduct animal studies to evaluate the system's performance in distinguishing malignant from benign tumors in vivo. Additional experiments will be designed to assess the method's sensitivity to quantifying oxygenation gain factor in breast tumors. This investigation will have important implications for studies identifying tumor's hypoxic regions. Tumor hypoxia is believed to be strongly associated with tumor progression, prognosis, and resistance to therapy. In the first year of this multidisciplinary postdoctoral training grant, the principal investigator acquires training in breast cancer and dynamic contrast enhanced MRI. The major focus is on optical imaging system development/improvement and performance evaluation through phantom studies. We managed to increase the data acquisition speed by a factor of 10, which enabled us to perform dynamic contrast enhanced diffuse optical tomography on phantoms for the first time.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2007
- Accession Number
- ADA472342
Entities
People
- Roshanak Shafiiha
Organizations
- University of California, Irvine