Exploration of Prostate Cancer Treatment Induced Neurotoxicity with Neuroimaging
Abstract
The current study sought to establish and test noninvasive neuroimaging methods to investigate the brain basis of cognitive decline in men on ADT. Healthy men showed better memory than men on ADT in a word learning task. Men with prostate cancer but who are not on ADT did not differ in memory from healthy older men. We found no group differences in several other cognitive tasks, including paragraph recall and the Trails task (a test of working memory). We compared brain activation during the word learning task in healthy men versus men on ADT. Although both groups activated the medial frontal gyrus when encoding words, activation was greater in men on ADT and men on ADT activate more regions, particularly in the prefrontal cortex, in order to encode information in memory. In conclusion, this pilot project suggests that neuroimaging methods can be useful in illuminating changes in brain activity that accompany behavioral loss of memory induced by ADT.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2007
- Accession Number
- ADA472360
Entities
People
- Jenri Janowsky
Organizations
- Oregon Health & Science University