Reaper-Induced Cytochrome C Release

Abstract

Apoptosis is a program of cellular suicide that removes individual cells from the midst of a living tissue without destroying overall tissue architecture. In response to chemotherapeutic agents, cells die by apoptosis. Moreover, inhibition of apoptosis is a hallmark of cancers. In this proposal, we proposed to understand the molecular basis for apoptosis induced by the proapoptotic protein, Reaper. Having purified and characterized a protein, Scythe, acting downstream of Reaper to trigger mitochondrial cytochrome c release and cell death, we wished to determine how these proteins might cooperate to execute the apoptotic program..

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2005
Accession Number
ADA472371

Entities

People

  • Eugene Gan

Organizations

  • Duke University Hospital

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemotherapeutic Agents
  • Cytochromes
  • Degradation
  • Demonstrations
  • Department Of Defense
  • Electronic Mail
  • Information Operations
  • Inhibition
  • Inhibitors
  • Mitochondria
  • Neoplasms
  • Programmed Cell Death

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Educational Psychology