Gene-Gene and Gene-Environment Interactions in the Etiology of Breast Cancer

Abstract

The purpose of this proposal is to evaluate gene-gene and gene-environment interactions in the etiology of breast cancer in two ongoing case-control studies, the Shanghai Breast Cancer Study (SBCS) and the Nashville breast health Study (NBHS) and in a proposed case-control study, the Breast Cancer in West Africa Study (BCAWS). An allelic variant of UGT1A1 (allele*28) was identified as a risk factor for postmenopausal breast cancer in Chinese women. A proposal was submitted and funded for the BCAWS study through U54-CA9140801 Adunyah (PI). Samples and surveys acquired from the BCAWS study are currently being analyzed.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2007
Accession Number
ADA472397

Entities

People

  • Dana R. Marshall
  • Olufemi J. Adegoke
  • Wei Xing Zheng

Organizations

  • Meharry Medical College

Tags

DTIC Thesaurus Topics

  • Africa
  • Breast Cancer
  • Chemical Synthesis
  • Chemistry
  • Diseases And Disorders
  • Epidemiology
  • Fish
  • Genetics
  • Health Services
  • Measurement
  • Medical Genetics
  • Medical Personnel
  • Neoplasms
  • Risk Factors
  • United States
  • Vegetables
  • West Africa

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