Silica-Immobilized Enzyme Reactors

Abstract

Recent studies have demonstrated the applicability and versatility of immobilized enzyme reactors (IMERS) for chemical and biochemical synthesis and analysis. The majority of IMER systems rely on enzymes immobilized to packed matrices within flow-through devices. This review focuses primarily on the use of silica as a support for enzyme immobilization and specific applications of the resulting silica-based IMERs. A number of recently published examples (from 2000 onwards) are discussed as model systems. The effect of various silica matrices and immobilization techniques upon the enzymatic properties and stability of the biocatalysts is considered. In particular, reports in which the carrier matrix is biologically-derived silica is emphasized and demonstrated as a versatile technique in terms of advantageous recovery, reuse and reproducibility.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2007
Accession Number
ADA472477

Entities

People

  • Heather R. Luckarift

Organizations

  • Air Force Research Laboratory

Tags

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Chemical Compounds
  • Chemical Engineering
  • Chemical Synthesis
  • Chemistry
  • Enzyme Inhibitors
  • Imines
  • Materials Science
  • Organic Chemistry
  • Pharmacology

Readers

  • Molecular and Cellular Biochemistry
  • Nanocomposite Materials Science
  • Systems Analysis and Design