Toxicity and Bio-Safety Evaluation of Magnetic Nanocrystals Designed for Nano-Medical Sensors

Abstract

Magnetic nanocrystals exhibit unique superparamagnetic behaviors. When they get into bio-medical systems, these magnetic nanocrystals have the potential to be utilized as probes and vectors for next-generation diagnosis and therapy. However, before one can utilize these nanomaterials in biology, it is important to assess if they have any deleterious properties in biological systems. In this project, toxicity and biosafety of magnetic nanocrystals under both in vitro and in vivo conditions are examined. In specific, cytotoxicity of inverse spinel metal ferrite nanocrystals with four different magnetic compositions "i.e. Fe3O4, MnFe2O4, CoFe2O4, NiFe2O4" on macrophage cells is investigated. Nanocrystal "Fe3O4" surface charge effect on cellular cytotoxicity are further examined. In addition to such in vitro cellular toxicity of nanocrystals, in vivo biodistribution of Fe3O4 nanocrystals are examined by labeling them with radio-active 111In-DTPA.

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Document Details

Document Type
Technical Report
Publication Date
Sep 15, 2006
Accession Number
ADA472526

Entities

People

  • Jin woo Cheon

Organizations

  • Yonsei University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Cells
  • Chemistry
  • Demographic Cohorts
  • Detection
  • High Temperature
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Materials
  • Materials Processing
  • Materials Science
  • Metals
  • Nanocrystals
  • Nanomaterials
  • Nanoparticles
  • Nanotechnology
  • Systems Biology
  • Toxicity

Readers

  • Materials Science and Engineering.
  • Nanoscale Plasmonic Nanotechnology
  • Toxicology/Environmental Toxicology