Polyphenols and Prostate Cancer Chemoprevention

Abstract

Asians consuming a diet high in soy products have reduced incidence of clinically manifested prostate cancers. Likewise, Asians have a long history of drinking tea. Significant components of these two staples of the traditional Asian diet are the polyphenolic compounds. The primary polyphenols associated with prostate chemoprevention are the soy isoflavone, genistein, and the tea catechin, (-)-epigallocatechin-3-gallate (EGCG). Another polyphenol that has recently received attention as a cancer suppressor is resveratrol, a component of grapes. The goal of this research was to investigate the potential of these three pure polyphenols, alone and in combination, to protect against prostate cancer in a model of spontaneously developing prostate cancer model (TRAMP mice). In this manner, it may be possible to ingest moderate amount of each of these foods/chemicals, as opposed to mega amounts of one, and receive an additive or synergistic protective effect without adverse effects with possible elevated exposure.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2007
Accession Number
ADA472702

Entities

People

  • Coral A. Lamartiniere

Organizations

  • University of Alabama

Tags

DTIC Thesaurus Topics

  • Additives (Chemicals)
  • Biomedical Research
  • Digestive System Processes
  • Drug Therapy
  • Maryland
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Suppressors
  • Universities

Fields of Study

  • Agricultural and Food sciences

Readers

  • East Asian Political and Security Studies within the Soviet Union
  • Nuclear Civil Defense.
  • Prostate Cancer Biology.

Technology Areas

  • Biotechnology