Evaluation of the Role of the Metastasis-Suppressor Gene MKK4/SEK1 in Transgenic Models of Prostate Cancer
Abstract
Metastasis-suppressor genes suppress the growth of metastases without affecting tumor growth. We have been studying the role of inactivation of one such metastasis suppressor gene, Map Kinase Kinase 4 (MKK4) in the process of metastatic colonization. Work proposed in this application was aimed at extending our ongoing studies in the AT6.1 model system into established transgenic models of prostate cancer and the use of transgenic approaches to test further MKK4's metastasis suppressor activity. Over the finding period of this grant we worked to test our hypotheses appropriately. During the course of these studies we found a need for changing our experimental design. To address these we established new collaborations and re-examined the potential role of MKK4 in tumorigenesis in both the TRAMP model and human cancers. In pursuing these studies we identified an unanticipated role MKK4 in the early growth of primary tumors and disseminated cells at metastatic sites.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2005
- Accession Number
- ADA472805
Entities
People
- Carrie W. Rinker-schaeffer
Organizations
- University of Chicago