A Study of Transrectal Tumor Oxygen Measurements in Patients with Clinically Localized Prostate Cancer

Abstract

This study of tumor hypoxia in prostate cancer patients has completed accrual and has yielded the largest cohort of its type world-wide. It has provided valuable information about the distribution of hypoxia in both malignant and non-malignant regions of the prostate gland the relationship between hypoxia and other important clinical and surgico-pathologic prognostic factors and the impact of androgen withdrawal on prostate cancer hypoxia. It has also provided a unique platform for investigating intrinsic biologic markers of tumors hypoxia and the relationship between hypoxia DNA repair and radioresistance in a truly relevant clinical context. Information about the relationship between hypoxia and patient outcome will follow at a later time once sufficient patient follow-up is achieved.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2006
Accession Number
ADA472885

Entities

People

  • Ants Toi
  • David Hedley
  • Joan Sweet
  • Michael Milosevic
  • Richard Hill
  • Robert Bristow
  • Tony Panzarella

Organizations

  • University Health Network

Tags

DTIC Thesaurus Topics

  • Androgens
  • Biomedical Research
  • Cancer
  • Diseases And Disorders
  • Glands
  • Health Services
  • Measurement
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Prostate
  • Prostate Cancer
  • Prostate Gland
  • Radiation Oncology
  • Radiotherapy
  • Tissues

Fields of Study

  • Medicine

Readers

  • Medical Imaging.
  • Molecular Biology and Genetics
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology