Campylobacter jejuni Induces Secretion of Proinflammatory Chemokines from Human Intestinal Epithelial Cells

Abstract

Campylobacter jejuni is a common cause of diarrhea in humans. While the pathogenic mechanisms of C. jejuni are not completely understood, host inflammatory responses are thought to be contributing factors. In this report, C. jejuni 81-176 is shown to up-regulate chemokines essential to inflammatory responses. Growth-related oncogene alpha (GRO alpha), GRO gamma, macrophage inflammatory protein 1, monocyte chemoattractant protein 1 (MCP-1), and gamma interferon-inducible protein 10 (gamma IP-10) mRNA transcription in INT-407 cells was enhanced within 4 h of bacterial exposure. Infection with viable campylobacters was necessary for sustained chemokine transcription and was NF-kappa B dependent. GRO alpha, gamma IP-10, and MCP-1 chemokine secretions were confirmed by immunological assays.

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Document Details

Document Type
Technical Report
Publication Date
Feb 02, 2005
Accession Number
ADA473268

Entities

People

  • Lan Hu
  • Thomas E. Hickey

Organizations

  • Naval Medical Research Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Bacteria
  • Biomedical Research
  • Cardiovascular System
  • Cells
  • Colitis
  • Culture Techniques
  • Diseases And Disorders
  • Epithelial Cells
  • Guillain-Barre Syndrome
  • Immunity
  • Infection
  • Lymphocytes
  • Monocytes
  • Navy
  • Proteins
  • Secretion
  • Transcription Factors

Fields of Study

  • Medicine

Readers

  • Analytical Mechanics
  • Immunology and Pathology