Chemoprevention of Breast Cancer by Mimicking the Protective Effect of Early First Birth

Abstract

We have successfully shown that in the rat estradiol, estradiol plus progesterone, and beta-HCG is protective against carcinogen-induced mammary tumorigenesis. Progesterone alone was not protective. Also, treatment with perphenazine was partially protective. We have continued to collect normal breast tissue from women undergoing elective reduction mammoplasty. Estrogen receptor and progesterone receptor have been characterized as well as cell proliferation have been characterized in these samples. Two chemoprevention protocols have been developed and are set to begin recruitment in the near future. The first will evaluate the role of high dose progestins on cell proliferation and gene expression profiles in the breast. The second protocol will evaluate the role of various oral contraceptive progestin doses on cell proliferation and gene expression profiles in the breast.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2007
Accession Number
ADA473365

Entities

People

  • Malcolm C Pike

Organizations

  • University of Southern California

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Carcinoma
  • Carrier Proteins
  • Cells
  • Cellular Structures
  • Chemistry
  • Connective Tissue
  • Data Sets
  • Drug Therapy
  • Epithelial Cells
  • Gene Expression
  • Hormones
  • Institutional Review Board
  • Lymphocytes
  • Medical Personnel
  • Proteins

Fields of Study

  • Medicine

Readers

  • Molecular Biology and Genetics
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology