Seamless Integration of Detection and Therapy for Breast Cancer using Targeted Engineered Nanoparticles

Abstract

This report summarizes the efforts of our team consisting of researchers from Rice University and M. D. Anderson Cancer Center, in the DoD funded CDMRP award towards the development of an integrated nano particle based imaging and therapy of breast cancer. We have made significant progress in our goals to demonstrate enhanced contrast in Optical Coherence Tomography (OCT) imaging tumors and photo thermal ablation using a single multifunctional particle. We have optimized the nanoshell that has a resonance in the near IR physiological water window, and can be used for both optical diagnostic imaging and photo thermal therapy. We have also explored other optical techniques for diagnosing malignant tumors from normal tissue.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2007
Accession Number
ADA473391

Entities

People

  • Naomi J. Halas

Organizations

  • Rice University

Tags

Communities of Interest

  • Advanced Electronics

DTIC Thesaurus Topics

  • Cells
  • Chemical Synthesis
  • Chemistry
  • Diagnostic Imaging
  • Genetics
  • Health Services
  • Materials Laboratories
  • Materials Processing
  • Materials Science
  • Materials Testing
  • Metallic Nanoparticles
  • Nanotechnology
  • Oncology
  • Optical Properties
  • Optics

Fields of Study

  • Physics

Readers

  • Image Processing and Computer Vision.
  • Nanoscale Plasmonic Nanotechnology
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech