Pyridinium Oxime Compounds as Antimicrobial Agents

Abstract

Pyridinium oxime compounds have been utilised by a number of military organisations as one of the antidotes for nerve-agent poisoning. In Canada, the preferred compound from this class is HI-6, which has been demonstrated to be tolerated at high doses without significant ill effects. In this study, HI-6 and 15 structural analogues have been examined for their antimicrobial properties against a series of model organisms: Bacillus cereus and B. anthracis Sterue (as models for virulent B. anthracis), Ochrobactrum intermedium (as a model for Brucella spp.), Mycobacterium marinum (as a model for M. tuberculosis), and Crithidia luciliae (as a model for Leishmania spp.). In general, the compounds were found to have little to no antimicrobial effect, with KJD-2-11, a thiourea derivative, being the most active in all the test systems.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2007
Accession Number
ADA473567

Entities

People

  • Bradley J. Berger
  • Marvin H. Knodel

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Analogs
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antidotes
  • Bacteria
  • Biological Factors
  • Classification
  • Complex Mixtures
  • Diseases And Disorders
  • Infection
  • Leishmania
  • Materials
  • National Security
  • Nerve Agents
  • Security
  • Tuberculosis

Fields of Study

  • Biology

Readers

  • Immunology
  • Neurotoxicology
  • Parasitology and Pharmacology of Malaria.