HLA Typing for Bone Marrow Transplantation

Abstract

Task 1 : Evaluate optimal short term storage parameters for stimulated and unstimulated leukapheresis (donor lymphocytes) and bone marrow products, including the type of storage media and the cell concentration, in addition to temperature and duration of storage before processing or infusion. Task 2: The NMDP has developed an algorithm that "predicts' high resolution HLA typing results on donor samples that exist in the Registry with only low or intermediate results reported. Perform validation of the NMDP algorithm by selecting donors randomly from our Registry that have low or intermediate DRB1 typing results and using the algorithm to predict the high resolution results and test the ability of the algorithm to predict KIR ligand mismatching in the absence of existing HLA-C locus results.

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Document Details

Document Type
Technical Report
Publication Date
Oct 31, 2007
Accession Number
ADA473611

Entities

People

  • Judy W. Davis
  • Michelle Setterholm
  • Steve M. Spellman

Organizations

  • National Marrow Donor Program

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Algorithms
  • Blood
  • Blood Cells
  • Bone Marrow
  • Bones
  • Cell Count
  • Cells
  • High Resolution
  • Infusions
  • Leukocytes
  • Lymphocytes
  • Medical Personnel
  • Minority Groups
  • Statistical Analysis
  • Stem Cells
  • Surveys
  • Transplants

Readers

  • Canine Service Warrior Training Program for Wounded Warriors in the Veterinary Industry, Supported by Donors.
  • Computational Modeling and Simulation
  • Immunology

Technology Areas

  • Biotechnology