Hypo-Fractionated Conformal Radiation Therapy to the Tumor Bed after Segmental Mastectomy
Abstract
The IDEA grant proposal tested the feasibility of a regimen of conformal hypofractionated radiotherapy (5 fractions in 2 weeks)directed to the original tumor bed with margins in a selected subset of post-menopausal women with breast cancer with a very low risk for local risk for local recurrence elsewhere in the breast. The relevance of this approach consists of the fact that if proven equivalent in efficacy it would be more patient-friendly (30 fractions over 6 weeks) convenient and economical. This final report demonstrated feasibility in all treated patients with minimal acute side effects. Among the 69 patients with at least 6 months follow-up late effects were limited to the rare occurrence of modest fibrosis and teleangectasia. With a median follow-up of 22.5 months in none of the patients breast cancer has recurred. Prone partial breast radiotherapy delivered by an external beam simple technique over 5 fractions was feasible and very well tolerated. These results need to be confirmed in a larger cohort of patients ideally in a multiinstitutional setting.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2007
- Accession Number
- ADA473890
Entities
People
- Silvia C. Formenti
Organizations
- New York University