Aurora-A as a Modifier of Breast Cancer Risk in BRCA 1/2 Mutation Carriers
Abstract
The AURORA-A/BTAK/STK15 gene encodes a centrosome-associated kinase that causes centrosome amplification failure of cytokinesis and aneuploidy when amplified and/or overexpressed in breast tumors. A number of gene association studies using matching breast cancer cases and controls have shown that the F31 I polymorphism in STKi 5 increases risk of breast. We hypothesized that the F31I polymorphism is associated with increased risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Using over 7,000 carriers of BRCA1 and BRCA2 deleterious mutations with a mean age of breast cancer diagnosis of 42 years we have shown that F31I has no influence on breast cancer risk. In parallel we have completed an association study of 2400 polymorphisms in other cell division regulatory genes in 800 breast cancer cases and 800 controls collected at the Mayo Clinic. A total of 144 polymorphisms displayed significant associations with breast cancer risk. An effort to validate these findings in 4000 BRCA1 and BRCA2 mutation carriers from six collaborating groups has been initiated but this is not yet complete.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2007
- Accession Number
- ADA473900
Entities
People
- Fergus J. Couch
Organizations
- Mayo Clinic