Castration Induced Neuroendocrine Mediated Progression of Prostate Cancer
Abstract
In the past twelve months we have demonstrated that bombesin stimulates the androgen receptor preferentially to a proximal androgen response element in the promoter region rather than in the enhancer region, which is primarily stimulated by androgens. We have shown that gastrin-releasing peptide prostate cancer cells have their growth in soft agar inhibited by the specific Src inhibitor AZD0530. This is a dose-dependent response. AZD0530 abolishes the nuclear translocation of the androgen receptor demonstrating specificity. We have also demonstrated that AZDO53O inhibits metastases of gastrin-releasing peptide prostate cancer cells in a SCID mouse model. Finally, we have delineated the downstream signaling cascades of neuroendocrine activation of androgen independent prostate cancer cell growth and have effectively inhibited these using the novel Src kinase inhibitor.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2006
- Accession Number
- ADA474464
Entities
People
- Christopher P Evans
Organizations
- California State University, Sacramento