An Evaluation of Stereoscopic Digital Mammography for Earlier Detection of Breast Cancer and Reduced Rate of Recall
Abstract
The goal of this project is to evaluate, in a screening context, stereoscopic digital mammography versus standard (non-stereo) digital mammography for earlier detection of breast lesions during screening and for reduction in the rate of patient recall for further work-up. As of July 2007, 1093 patients at elevated risk for the development of breast cancer have been enrolled. Each patient receives both a standard screening examination and a stereoscopic screening examination which are read independently by different radiologists. If a suspicious finding is reported from either reading, the patient is recalled for standard clinical workup examinations, which form the basis for lesion truth. Compared to standard digital mammography, stereo mammography is significantly reducing false positive lesion detections by 48% (p< 0.0001), and significantly reducing false negative reports by 40% (p< 0.06). ROC analysis of the readers' judgments of the likelihood that a finding is real show significantly greater accuracy for stereo, Az = 0.78, than for standard, Az = 0.55 (p=0.0001).
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2007
- Accession Number
- ADA474572
Entities
People
- David J. Getty
Organizations
- BBN Technologies