Chemistry, Biochemistry, Pharmacology, and Toxicology of CS and Synthesis of Its Novel Analogs
Abstract
Of the potential five groups of less-than-lethal riot control and crowd management agents, three groups, namely co-chloroacetophenones (CN), benzylidene malononitriles (CS-type), and dibenzooxazepines (CR) have found frequent use. Of the three groups, chlorobenzylidene malononitrile (CS) is the most popularly used non-lethal agent in riot control situations and military exercises. With a view to improve its properties and enhance its effectiveness, 15 new CS analogs incorporating fluorine and fluorine-containing groups have been synthesized using microwave irradiation and novel catalysts. The structures and physical properties and mass spectral characterization of this group of highly potent CS-type agents are described herein.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2007
- Accession Number
- ADA474594
Entities
People
- Dennis K. Rohrbaugh
- H. D. Durst
- Shekar Munavalli
Organizations
- Leidos