A Novel Strategy for Controlling the Metastatic Phenotype: Targeting the SNAG Repression Domain in the SNAIL Zinc-Finger Protein
Abstract
BCRP Award has funded fundamental new discoveries into how a key protein involved in the metastatic process of breast cancer functions. We have discovered the following: 1. The SNAIL zinc finger repressor must bind its obligate co-repressor AJUBA, in order to repress e-cadherin and initiate metastasis. 2. The AJUBA interaction is direct and highly specific and this complex can be found at endogenous SNAIL target genes. 3. The binding requires the 20 amino acid SNAG domain of SNAIL and a single LIM domain of AJUBA. This biding forms a well-defined protein-protein interaction, which may be targeted by small molecules to interfere with the metastatic process during breast cancer progression.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2007
- Accession Number
- ADA474599
Entities
People
- Frank J. Rauscher Iii
Organizations
- University of Pennsylvania