Corynebacterial Necrohemorrhagic Cystitis in Two Female Macaques
Abstract
We describe severe necrohemorrhagic cystitis in a female rhesus macaque and a female cynomolgus macaque due to colonization of the urinary bladder by Corynebacterium sp. Clinically, both macaques presented with perineal bleeding and depression and, despite extensive and prolonged treatment, succumbed to the disease. At necropsy, the contents of the urinary bladders in both cases were hemorrhagic to greenish black, and the bladder mucosa was necrotic. The major microscopic fi nding in each case was transmural necrohemorrhagic cystitis, with vasculitis, fi brin thrombi, and myriad gram-positive coryneform bacilli. Corynebacterium renale, Streptococcus acidominimus, and S. oralis were cultured from the urinary bladder of the rhesus macaque, and a nondiphtheritic Corynebacterium was cultured from the urinary bladder of the cynomolgus macaque. Neither animal had any other noteworthy pathologic lesions unrelated to bacterial cystitis. Corynebacterial necrohemorrhagic cystitis therefore was determined to be the cause of death in both animals. To our knowledge, this is the first report of corynebacterial cystitis in nonhuman primates.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2007
- Accession Number
- ADA474646
Entities
People
- Anne M. Maclarty
- Edward L. Stevens
- Nancy A. Twenhafel
- Norman Kreiselmeier
Organizations
- United States Army Medical Research Institute of Infectious Diseases