Predicting Bone Metastatic Potential of Prostate Cancer Via Computational Modeling of TGF-Beta Signaling

Abstract

We demonstrate that transforming growth factor beta 1 (TGF-1), a common growth factor in the bone marrow, reduces the adhesion of metastatic prostate cancer (PC) cells to bone marrow endothelial cells (BMEC), but increases the adhesion of these same cells to collagen type I, a major component of the bone matrix. Also, we show that metastatic PC cells are inhibited by TGF-1 in a dose dependent fashion. The expression of TGF-1 receptors type I and II are increased in metastatic PC cells and these observations provide a unique opportunity to use mathematical modeling to decipher the complex TGF-1 signaling pathway required for PC metastasis. We are well on our way to understanding this pathway with the hope of using the information gained to better access the metastatic potential of PC.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2007
Accession Number
ADA474707

Entities

People

  • Babtunde Ogunnaike
  • Carlton R. Cooper

Organizations

  • University of Delaware

Tags

DTIC Thesaurus Topics

  • Adhesion
  • Bone And Bones
  • Bone Marrow
  • Bones
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Collagen
  • Endothelial Cells
  • Epithelial Cells
  • Growth Factors
  • Neoplasms
  • Peptide Growth Factors
  • Peptides
  • Prostate
  • Prostate Cancer

Fields of Study

  • Medicine

Readers

  • Computer Science/Computer Engineering/Data Science/Digital Signal Processing.
  • Molecular Biology and Genetics
  • Trauma Surgery or Emergency Medicine.