A Rat Model of Sytemic Chemotherapy for Breast Cancer to Evaluate and Treat Chemobrain

Abstract

The primary objective of this project was to develop an animal model to measure possible cognitive deficits resulting from chemotherapy. We have established a rat model of multidose human-equivalent combination chemotherapy using cyclophosphamide methotrexate and 5-fluorouracil (CMF) that recapitulates the physical symptoms of chemotherapy treatment. We investigated the effects of this regimen on learning and memory as well as on the production and survival of new neurons in the hippocampus (neurogenesis). We found no statistically significant differences between control and CMF animals on any measure of learning or memory nor with respect to neurogenesis.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2007
Accession Number
ADA474717

Entities

People

  • Kevin C. Little

Organizations

  • University of Auckland

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Antidepressants
  • Blood-Brain Barrier
  • Body Weight
  • Brain
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemotherapy
  • Computer Vision
  • Drug Therapy
  • Field Tests
  • Neoplasms
  • Neurons
  • Object Recognition
  • Peptides
  • Therapy

Fields of Study

  • Biology
  • Medicine

Readers

  • Allergy and Immunology.
  • Neuroscience
  • Oncology (Cancer Research).