D2 as an Integrator of Oncogenic Stimuli in Breast Cancer
Abstract
This proposal focused on the role of Inhibitor of Differentiation (Id) proteins, which are transcription factors, in mammary gland development and carcinogenesis. Although Id2 regulates mammary gland growth and development and is important for myc-induced transformation of certain cell types, its role in breast cancer has not been thoroughly addressed. We have found that Id2 is upregulated in two mouse models of breast cancer: one that involves hormone-induction of carcinogenesis and the other involves overexpression of HER2/neu. In contrast, Id1 expression is reduced in both models. These data suggest that Id2 may be a common integrator of oncogenic stimuli in breast and that Id1 may suppress breast carcinogenesis. The goals of this work were to determine, using transgenic mouse models, if Id2 is necessary and sufficient for mammary gland tumorigenesis in mice. If so, this would suggest that Id2 or processes regulated by this transcription factor may serve as useful prognostic markers or therapeutic targets in breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2007
- Accession Number
- ADA474744
Entities
People
- Ruth A Keri
Organizations
- Case Western Reserve University