Therapeutic Vascular Targeting and Irradiation: Correlation of MRI Tissue Changes at Cellular and Molecular Levels to Optimizing Outcome
Abstract
Vascular targeting agents (VTA) are able to disrupt tumor vasculature, leading to extensive tumor necrosis. Interesting findings have shown that VTA kills cells predominantly in the more hypoxic tumor center, while the better perfused peripheral rim is less affected. This apparently limits the effectiveness of such agents and rapid regrowth of tumor residues occurs. However, these findings suggest a potential of a combination of VTA with treatments specifically targeting the viable tumor rim. Radiation can certainly be expected to be most effective against the well-perfused and oxygenated cell populations at the peripheries of the tumors. One major goal of this project is to fully understand and precisely assess the dynamic changes in blood perfusion and oxygenation after VTA, so that we may predict response and optimize the therapy. I propose to use in vivo MRl to measure and assess physiological changes, e.g. tumor blood perfusion and dynamic tissue oxygenation, in the tumors before and after treatment. I believe non-invasive MRl approaches may provide a valuable prognostic tool to predict the response of specific breast tumors to VTA.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2007
- Accession Number
- ADA474941
Entities
People
- Dawen Zhao
Organizations
- University of Texas at Dallas