Hyaluronan-CD44 Interactions Decrease the Metastatic Potential of Breast Cancer Cells

Abstract

The adhesion receptor CD44 is known to decrease the metastatic potential of breast cancer cells in vivo. This study focuses on understanding the mechanisms by which CD44 inhibits breast cancer cell invasion. We have found that the interaction between CD44 and Hyaluronan leads to decreased phosphorylation of FAK. Additionally, this interaction also leads to decreased transcription of the metalloprotease MMP9. Together, these mechanisms provide significant insight into how CD44 inhibits the movement of breast cancer cells away from their primary site.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2007
Accession Number
ADA474955

Entities

People

  • Jose I. Lopez

Organizations

  • University of Arizona

Tags

DTIC Thesaurus Topics

  • Adhesion
  • Antibodies
  • Biomedical Research
  • Breast Cancer
  • Cell Membrane Structures
  • Cells
  • Collagen
  • Department Of Defense
  • Disease Attributes
  • Diseases And Disorders
  • Electronic Mail
  • Epithelial Cells
  • Epithelium
  • Information Operations
  • Neoplasms
  • Phosphorylation

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology (Cancer Research).
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.