Proof of Concept for Systematic Collection of Optimal Molecular Quality Anatomically Oriented Normal Prostate From Diverse Age and Race Transplant Donors
Abstract
The lack of availability of high-quality whole normal human prostate tissue from subjects of various ages and races impedes prostate cancer research in several ways. It prevents examination of prostate molecular pathologic changes on a time continuum, thus preventing the establishment of a definition of what the range of normal cellular activity is in a human male prostate for any one age or race. Just as important, the lack of availability of well-curated whole normal prostate tissue across the age and race spectrum impedes the development of truly representative animal models of human disease. This project has completed or partially completed several key steps, each of which must be accomplished to a high degree of quality in order for this Resource Development prototype project to prove feasibility of a scaled-up version of this work, which will be necessary to provide sufficient sample numbers for many types of research. These steps are: IRB approval, Tissue Availability, Tissue Collection, Tissue Archiving and Preparation, Tissue Sharing Protocol, and Database Integration. Progress in each aspect is discussed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2007
- Accession Number
- ADA475128
Entities
People
- G. S. Bova
Organizations
- Johns Hopkins University