The Role of the Low Molecular Weight (LMW) Isoforms of Cyclin E in Breast Cancer Tumorigenesis

Abstract

Cyclin E is a positive regulator of the G1 to S phase transition of the cell cycle. In complex with CDK2 it is responsible for cells passing the restriction point, committing the cell to a round of DNA replication. Previously this laboratory found that cyclin E is overexpressed and present in lower molecular weight (LMW) isoforms in breast cancer cells and tumor tissues compared to normal cells and tissues. To investigate the role of the LMW forms of cyclin E in tumorigenesis we have developed a model system of non-tumorigenic breast cells overexpressing the individual isoforms of cyclin E. Using this model system we have determined that the LMW forms of cyclin E are associated with increased kinase activity that results in cell cycle deregulation, chromosomal instability and nare.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2007
Accession Number
ADA475147

Entities

People

  • Hannah Wingate

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chromosome Structures
  • Chromosomes
  • Genetics
  • Genomic Instability
  • Growth Factors
  • Instability
  • Medical Personnel
  • Molecular Weight
  • Neoplasms
  • Phase
  • Proteins

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics