Natural History of Plexiform Neurofibromas in NF1
Abstract
The overall goal of this study is to use volumetric MRI to define the natural history of untreated plexiform neurofibromas in patients with NF1. Recruitment has been completed including patients with head and neck or trunk and extremity plexiform neurofibromas with serial MRI studies done over a three year period. Volumetric analysis is nearly completed delayed by a two year hiatus in the study when the PI moved from Boston to Birmingham. In addition to completing the volumetric analysis we plan to validate the volumetric data by complete review of all MRIs done on all patients and use of two independent approaches to volumetric analysis. This will insure that data on tumor volumes is reliable given that several years have elapsed between initial and final studies. It will also link the data in the present study to two ongoing initiatives: the NF Consortium which is conducting clinical trials and the Children's Tumor Foundation funded plexiform neurofibroma imaging repository.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2007
- Accession Number
- ADA475213
Entities
People
- Bruce R. Korf
Organizations
- University of Alabama