Nanospheric Chemotherapeutic and Chemoprotective Agents

Abstract

Purpose: Investigate the delivery of camptothecin in the presence of vitamin D3 with triblock copolymer-derived nanospheres that will increase the solubility of both of the drugs and provide protection to the camptothecin's lactone ring, resulting in its increased bioavailability to breast cancer cells. To date we have done the evaluation of two nanosphere formulations containing short alkyl pendent chain (DTB-SA/5K, Butyl) and/or benzyl ring (DTBn-SA/5K) Drug-binding efficiency of these nanospheres was evaluated for a constant quantity of the nanospheres with varying concentrations of the CPT and/or VD3. HPLC methods were developed and validated for quantitative determination of CPT and VD3 in the copolymer systems. To elucidate the synergistic effect of vitamin D3 on increasing the binding efficiency of CPT, different CPT to VD3 feed ratio were investigated. Results: The binding efficiency of VD3 in the presence of CPT. VD3 binding efficiency is not affected by the presence of the camptothecin, but is strongly affected by the nanospheres composition. Work was delayed by contract difficulties at Rutgers, but is now underway.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2007
Accession Number
ADA475293

Entities

People

  • Larisa Sheihet

Organizations

  • Rutgers University–New Brunswick

Tags

DTIC Thesaurus Topics

  • Alkaloids
  • Block Copolymers
  • Breast Cancer
  • Contracts
  • Copolymers
  • Efficiency
  • Hydrophilic Properties
  • Hydrophobic Properties
  • Macromolecules
  • Molecular Weight
  • Molecules
  • Neoplasms
  • Particles
  • Physical Properties
  • Polymers
  • Self Assembly
  • Solubility

Fields of Study

  • Medicine

Readers

  • Analytical Chemistry
  • Molecular Biology and Genetics
  • Nanocomposite Materials Science

Technology Areas

  • Microelectronics