Genomic Instability and Breast Cancer
Abstract
Genomic instability is one of the key initiating events that lead to breast cancer development. We would like to gain further insights into the regulation of genomic stability and how the disruption of this regulation contributes to tumorigenesis. In the past year, we have identified several new components in the DNA damage pathway that act upstream of BRCA1. We have also discovered a novel link between aging and breast cancer development. In addition, we have established a platform for large-scale purification of protein complexes for the study of networks involved in breast cancer development. On top of these, we are also interested in developing novel agents for cancer treatment. In this arena, we have set up a screen for cytotoxic agents that would target Chfr-deficient tumor cells. In a collaborative study, we identified compounds that would disrupt the interaction between BRCA1 and its binding partners for potential use as radiation sensitizer. Moreover, we have initiated a collection of stable cell lines expressing various protein kinases for the screening of specific kinase inhibitors. Together, these studies will help us understand breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2007
- Accession Number
- ADA475489
Entities
People
- Junjie Chen
Organizations
- Yale University