The Role of Protein Kinase D (PKD) Signaling in Breast Cancer Cell Migration and Invasion

Abstract

The goal of my project as outlined in the original application is to analyze the role of Protein Kinase D (PKD) in breast cancer cell motility, the phenotype critical for metastasis. The work I have conducted includes the establishment of gene expression system in breast cancer cell lines vital for a comprehensive study of contribution of PKD towards invasive migration. By means of these systems, I have demonstrated that loss or inhibition of PKD results in a migration defect phenotype in a highly metastatic breast cancer cell line. I have also found that loss or inhibition of PKD results in apoptotic cell death.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2007
Accession Number
ADA475517

Entities

People

  • Claudine Christoforides

Organizations

  • Beth Israel Deaconess Medical Center

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Carcinoma
  • Cell Line
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Genetics
  • Infection
  • Inhibition
  • Inhibitors
  • Migration
  • Neoplasms
  • Phenotypes

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Nuclear and Radiation Engineering.