Development of Antibodies Against Novel Cell Surface Proteins in Hormone Refractory Prostate Cancer
Abstract
The overall goal of this project is to validate novel targets and develop new antibody reagents for the diagnostic imaging and treatment of prostate cancer. N-cadherin is a cell surface marker that is overexpressed in hormone refractory prostate cancer which could have possible diagnostic or therapeutic utility. We observed that the cadherin profiles of certain prostate cancer cell lines and xenografts correlated with their level of invasiveness and that amongst certain hormone refractory xenograft models, there was a consistent upregulation of N-Cadherin when compared to its androgen dependent counterpart. We sought to validate N-Cadherin as a target in hormone refractory prostate cancer and determine if blockade of this pathway could decrease invasion and metastasis. We generated specific monoclonal antibodies against different domains to determine if blockade could decrease invasion and metastasis. Ongoing in vitro and in vivo studies will determine if this protein can be validated as an effective imaging and therapeutic target.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2007
- Accession Number
- ADA475520
Entities
People
- Zev Wainberg
Organizations
- University of California, Los Angeles