Analysis of Morphogenic Effect of hDAB2IP on Prostate Cancer and its Disease Correlation
Abstract
Imbalance of apoptotic and/or survival signaling cascade is a hallmark of malignant cell. In prostate cancer (PCa), constitutive activation of phosphatidylinositol 3-kinase (PI3K)-Akt/PKB and inactivation of apoptosis-stimulated kinase (ASK1)-JNK pathway signaling are often detected in metastatic cell. Understanding the underlying mechanism leading to such alternations will provide a better treatment strategy to control the terminal stage of this disease. In this project, we have proposed that DAB2IP protein, a novel RASGAP, is a part of homeostatic machinery and plays an important in modulating signal pathways elicited by exogenous survival/death stimuli. Our data clearly demonstrated that DAB2IP is a novel scaffold protein that complexes with key proteins involved in cell growth or death. The outcome of this study has led us to unveil a new mechanism of DAB2IP, which provides a better understanding how PCa cells switch from survival to death under the stimuli of exogenous signals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2007
- Accession Number
- ADA475757
Entities
People
- Jer-Tsong Hsieh
Organizations
- University of Texas at Dallas