Development of Hemostatic Agents

Abstract

To translate investigational hemostatic agents developed in the rat model to swine models of lethal groin injury and liver laceration. This objective evaluated the efficacy of patch and granule formulations of capsaicin (CP-305) in normal and coagulopathic swine models. The thermal stability of the dmg patches was studied at elevated temperatures to assess shelf life of the hemostatic agent. The remaining objectives were to study the mechanism of action of vanilloid compounds on whole blood aggregation and develop bio-degradable vanilloid compounds.

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Document Details

Document Type
Technical Report
Publication Date
Jan 31, 2008
Accession Number
ADA476310

Entities

People

  • Bob M. Moore Ii

Organizations

  • University of Tennessee

Tags

DTIC Thesaurus Topics

  • Arteries
  • Bandages
  • Battlefields
  • Blood
  • Blood Coagulation
  • Blood Volume
  • Compression
  • Health Services
  • Heart Rate
  • Hemorrhage
  • Hemostasis
  • Resuscitation
  • Standards
  • Survival
  • Thermal Stability
  • Vascular System Injuries
  • Wounds And Injuries

Fields of Study

  • Agricultural and Food sciences

Readers

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